气虚血瘀证贯穿于中风病的始终，益气活血为治疗中风之首。中药补阳还五汤由黄芪、当归、川芎、桃仁、红花、赤芍和地龙等药物组成，具有补气活血、通经活络功效，可有效改善脑血流及血液流变，拮抗兴奋性氨基酸毒性及合理调控一氧化氮合酶的表达，拮抗脑缺血及再灌注损伤，主要用于治疗缺血性脑卒中及其后遗症[1-5]，对老年脑缺血损伤有保护作用，机制可能与其抑制细胞因子及细胞凋亡有关[3-4]。 | Qi supplementation and activation of the blood circulation play an important role in the treatment of stroke. Buyang Huanwu decoction (BHD) consists of milkvetch root, Chinese angelica, red peony root, earthworm, peach seed, safflower and Szechwan lovage rhizome. BHD has been shown to increase Qi, promote blood circulation, dredge meridians, and activate collaterals. In addition, it effectively improves cerebral blood flow and blood rheology, resists excitatory amino acid toxicity, regulates nitric oxide synthase expression, prevents cerebral ischemia/reperfusion damage, and is mainly used to treat ischemic stroke and sequelae [1–2]. | Stroke patients are always combined with Qi deficiency and blood stasis syndrome. Supplementing Qi and activating blood circulation method plays an important role in treatment of stroke. Buyang Huanwu decoction (BHD) consists of milkvetch root, Chinese angelica, red peony root, earthworm, peach seed, safflower and szechwan lovage rhizome. BHD invigorates Qi, promotes blood circulation, dredges meridians, and activates collaterals; BHD effectively improves cerebral blood flow and blood rheology, resists toxicity of excitatory amino acids, regulates nitric oxide synthase expression, prevents cerebral ischemia/reperfusion damage, and it is mainly used for treating ischemic stroke and its sequelae [1-5]. BHD has protective effects on ischemic brain damage, and the mechanism may be correlated to its inhibitory effect on cell apoptosis [3-4]. |
